Differin

Differin gel is a Rosacea and Acne Treatment medication that has the main active ingredient, Adapalene, belongs to the category of retinoids, chemical compounds related to vitamin A. It is indicated for the local treatment (application on the skin) of acne vulgaris with blackheads (relief of punctual skin), papules (small raised skin lesions without pus) and pustules (small skin lesions that contain pus). Differin Gel ingredients include the active substance is adapalene. The other ingredients are carbomer 940, propylene glycol (E1520), poloxamer 182, disodium edetate, methyl parahydroxybenzoate (E218), phenoxyethanol, sodium hydroxide, and purified water.

The differin gel uses the active ingredient, Adapalene binds, like tretinoin, to specific nuclear receptors for retinoic acid, but unlike tretinoin, it does not bind to cytosolic receptors. Adapalene administered topically is comedolytic in the mouse-rhino model and also has effects on abnormal processes of keratinization and epidermal differentiation, both present in the pathogenesis of acne vulgaris. The mechanism of action of adapalene may be a normalization of the differentiation of follicular epithelial cells, resulting in a decrease in the formation of microcomedones. In standard anti-inflammatory assays, adapalene is superior to reference retinoids, both in vivo and in vitro. Pharmacodynamically, it inhibits the chemotactic and chemokinetic responses of human polymorphonuclear leukocytes and the metabolism by lipoxidation of arachidonic acid to pro-inflammatory mediators. This profile suggests that the mediating cells of the inflammatory component of acne may be modified by adapalene. Studies in human patients provide clinical evidence that adapalene topical is effective in reducing the inflammatory component of acne (papules and pustules).

Differin Gel is specifically designed to combat acne symptoms. This gel uses the active ingredient adapalene, which is a type of vitamin A. It unlocks the pores and aids in the regeneration of skin cells to help prevent the appearance of pimples. Additional Differin gel uses include being to utilsed to unblocks pores and sebaceous glands.

To get the maximum benefits from this medicine, you must follow the doctor’s instructions. This will help reduce the chance of experiencing side effects.

1. Apply only in external
2. Unless your doctor tells you otherwise, apply before going to
3. Clean and dry the area before
4. Use your fingertips to spread a thin layer of gel on the

Wash your hands before using it.

Differin should be applied to acne-affected areas once daily before bedtime and after washing. A thin film of gel or cream is applied, avoiding the eyes, lips, and membranes mucous membranes and the wings of the nose. Make sure that the areas to be treated are dry before application. Clinical improvement is expected to be evident within four to eight weeks of treatment. Since in the acne treatment is used to alternate therapies, it is recommended to evaluate the continued improvement of patients after three months of Differin treatment. Differine’s skin safety has been demonstrated over a period of six months. If the patient uses cosmetics, they must not be comedogenic or astringent. The safety and efficacy of Differin have not been studied in children below 12 years of age.

As with any other medicine, there is a possibility of developing side effects when using Differin. If you experience an allergic reaction you should see your doctor as soon as possible.

Common (1 in 10 people or less):

• Dry, irritated, or inflamed skin in the application

Uncommon (1 in 100 people or less):

• Burns, burning, peeling, acne, or contact

Unknown frequency:

• Inflamed skin, irritation of the eyelids