trajenta

$50.00

Trajenta belongs to the class of drugs known as DPP-4 inhibitors, which are used to treat type 2 diabetes. Trajenta works by increasing the amount of incretin produced by the intestine. Incretin is a natural hormone that increases insulin levels when blood sugar levels are high – after a meal for example – and reduces the amount of sugar produced by the body. Trajenta is usually taken together with other medications to control the blood sugar levels of adults with type 2 diabetes. It is designed to be used as part of a holistic diabetes management plan that also includes a diet and exercise regimen.

What is Trajenta?

Trajenta contains the active substance linagliptin which belongs to a group of medicines known as “oral antidiabetics”. Oral antidiabetics are used to treat high blood sugar levels. They work by helping the body lower the level of sugar in your blood.

How does it work?

Linagliptin is an inhibitor of the enzyme DPP-4 (dipeptidyl-peptidase 4, EC 3.4.14.5), an enzyme that is involved in the inactivation of the incretin hormones GLP-1 (glucagon-like peptide 1) and GIP (insulinotropic dependent polypeptide glucose). These hormones are rapidly broken down by the enzyme DPP-4. Both incretin hormones are involved in the physiological regulation of glucose homeostasis. Incretins secrete at a low basal level throughout the day and their levels increase immediately after food intake. GLP-1 and GIP increase biosynthesis and insulin secretion by pancreatic beta cells in the presence of normal and elevated blood glucose levels. In addition, GLP-1 also reduces glucagon secretion by pancreatic alpha cells, resulting in reduced hepatic glucose production. Linagliptin effectively binds to DPP-4 reversibly and thus leads to a sustained increase and a prolongation of levels of active incretin. Linagliptin increases insulin secretion and decreases glucagon secretion in a glucose-dependent manner, leading to an overall improvement in glucose homeostasis. Linagliptin selectively binds to DPP-4 and exhibits an in vitro selectivity of> 10,000-fold against DPP-8 or DPP-9 activity.

What are the benefits of taking it?

Trajenta is used to treat “type 2 diabetes” in adults if the disease cannot be adequately controlled with oral anti-diabetic medicine (metformin or sulfonylureas) or diet and exercise alone. Trajenta can be used together with other antidiabetic medicines, eg eg, metformin, sulfonylureas (eg glimepiride, glipizide), empagliflozin, or insulin.

It is important that you follow the diet and exercise advice given by your doctor or nurse.

How do I use it and its dosage?

Always follow exactly the instructions of this medicine given by your doctor. If in doubt, consult your doctor or pharmacist again.

The recommended dose of Trajenta is one 5 mg tablet once a day.

You can take Trajenta with or without food.

The doctor may prescribe Trajenta together with another oral antidiabetic medicine. Remember to take all medications as directed by your doctor to get the best results for your health.

Side effects & precautions

Like all medicines, this medicine can cause side effects, although not everybody gets them.

Some symptoms need immediate medical attention

You should stop taking Trajenta and see your doctor immediately if you experience the following symptoms of low blood sugar: tremor, sweating, anxiety, blurred vision, tickling of the lips, paleness, mood swings, or confusion (hypoglycemia). Hypoglycemia (frequency: very common, may affect more than 1 in 10 people) is an identified adverse effect when Trajenta is taken together with metformin and a sulfonylurea.

Some patients have had allergic reactions (hypersensitivity; infrequent frequency, may affect up to 1 in 100 people) while taking Trajenta alone or in combination with other medicines for the treatment of diabetes, which can be serious, including wheezing and shortness of breath (Bronchial hyperresponsiveness; frequency not known, the frequency cannot be estimated from the available data). Some patients had a rash (skin reaction; uncommon frequency), hives (hives; rare frequency, may affect up to 1 in 1,000 people) and swelling of the face, lips, tongue, and throat that can cause difficulty breathing or swallowing (angioedema; rare frequency). If you experience any of the signs of illness mentioned above, stop taking Trajenta and see your doctor quickly. Your doctor may prescribe a medicine to treat your allergic reaction and a different medicine for your diabetes.

Some patients have experienced inflammation of the pancreas (pancreatitis; rare frequency, may affect up to 1 in 1,000 people) while taking Trajenta alone or in combination with other medications to treat diabetes.

Stop taking Trajenta and see a doctor immediately if you notice any of the following serious side effects:

Persistent and severe pain in the abdomen (stomach area), which can be reflected in the back, as well as nausea and vomiting, as this could be an indication of an inflamed pancreas (pancreatitis).

Some patients have experienced the following side effects while taking Trajenta alone or in combination with other medicines for the treatment of diabetes:

  • Common: elevated levels of the enzyme lipase in the blood.
  • Uncommon: inflammation of the nose or throat (nasopharyngitis), cough, constipation (in combination with insulin), high levels of the enzyme amylase in the blood.
  • Rare: blisters on the skin (bullous pemphigoid).

Warnings and precautions

Talk to your doctor, pharmacist, or nurse before taking Trajenta if you:

  • you have type 1 diabetes (your body does not make insulin) or diabetic ketoacidosis (a complication of diabetes with high blood sugar levels, rapid weight loss, nausea, or vomiting). Trajenta should not be used to treat these medical conditions.
  • If you are taking an antidiabetic medicine known as a “sulfonylurea” (eg glimepiride, glipizide), your doctor may want to reduce your sulfonylurea dose when you take it together with Trajenta to prevent your blood sugar levels from dropping too low.
  • you have had allergic reactions to any other medicines you take to control the amount of sugar in your blood.
  • have or have had a disease of the pancreas.
types

– – 0.5mg, – – 1.7mg, – – 1mg, – – 2 Month Starter Pack (1 x 0.25mg & 1 x 0.5mg), – – 2.4mg, – 0.25mg, – 3 Month Starter Pack (1 x 0.25mg, 1 x 0.5mg & 1 x 1.0mg), 0.25mg Starter Dose 1 Pack, 0.3mg 168 Tablets (6 Months), 0.3mg 84 Tablets (3 months), 0.5mg 1 Pack, 0.625mg 168 Tablets (6 Months), 0.625mg 84 Tablets (3 months), 1 pack, 1.25mg 168 Tablets (6 Months), 1.25mg 84 Tablets (3 months), 1/10 Tablets – 168 Tablets (6 Months), 1/10 Tablets – 84 Tablets (3 months), 100mcg 1 Inhaler, 100mcg 12 Patches (3 months), 100mcg 24 Patches (6 months), 10mg 28 Tablets, 10mg 56 Tablets, 10mg 84 Tablets, 14mg 30 Tablets, 150mcg Junior 1 pen, 150mcg Junior 2 Pens, 1mg 1 Pack, 1mg 168 Tablets, 1mg 252 Tablets, 1mg 84 Tablets, 1mg/0.5mg 168 Tablets, 1mg/0.5mg 252 Tablets, 1mg/0.5mg 84 Tablets, 1mg/1g 1 box, 1mg/1g 2 boxes, 1mg/1g 3 boxes, 2 pack, 2.5mg/1000mg 112 Tablets, 2.5mg/1000mg 168 Tablets, 2.5mg/1000mg 56 Tablets, 2.5mg/850mg 112 Tablets, 2.5mg/850mg 168 Tablets, 2.5mg/850mg 56 Tablet, 2/10 Tablets – 168 Tablets (6 Months), 2/10 Tablets – 84 Tablets (3 months), 200mcg 1 Inhaler, 200mg 112 Tablets, 200mg 168 Tablets, 200mg 56 Tablets, 250mcg 1 Inhaler, 25mcg 24 Patches (3 Months), 25mcg 48 Patches (6 Months), 25mg 28 Tablets, 25mg 56 Tablets, 25mg 84 Tablets, 2mg 168 Tablets, 2mg 252 Tablets, 2mg 84 Tablets, 2mg/1mg 168 Tablets, 2mg/1mg 252 Tablets, 2mg/1mg 84 Tablets, 300mcg Adult 1 pen, 300mcg Adult 2 Pens, 300mg 112 Tablets, 300mg 168 Tablets, 300mg 56 Tablets, 30mg SR 28 Tablets, 30mg SR 56 Tablets, 30mg SR 84 Tablets, 37.5mcg 24 Patches (3 Months), 37.5mcg 48 Patches (6 Months), 3mg 30 Tablets, 400mg 112 Tablets, 400mg 168 Tablets, 400mg 56 Tablets, 40mcg 16 Patches, 40mcg 24 Patches, 40mcg 48 Patches, 40mcg 8 Patches, 40mg 112 Tablets, 40mg 168 Tablets, 40mg 56 Tablets, 500mcg/500g 1 box, 500mcg/500g 2 boxes, 500mcg/500g 3 boxes, 50mcg 1 Inhaler, 50mcg 12 Patches (3 months), 50mcg 24 Patches (3 Months), 50mcg 24 Patches (6 months), 50mcg 48 Patches (6 Months), 5mg 28 Tablets, 5mg 56 Tablets, 5mg 84 Tablets, 75mcg 12 Patches (3 months), 75mcg 24 Patches (6 months), 75mcg 48 Patches (6 Months), 7mg 30 Tablets, 80mcg 24 Patches, 80mg 112 Tablets, 80mg 168 Tablets, 80mg 56 Tablets, Accuhaler – 1 Pack, Accuhaler – 2 Packs, Aceclofenac (Generic) 100mg 120 Tablets, Aceclofenac (Generic) 100mg 180 tablets, Aceclofenac (Generic) 100mg 60 Tablets, Alendronic Acid (Generic) Daily 10mg 28 Tablets, Alendronic Acid (Generic) Daily 10mg 56 Tablets, Alendronic Acid (Generic) Daily 10mg 84 Tablets, Arcoxia 120mg 28 Tablets, Celebrex 100mg 120 Capsules, Celebrex 100mg 180 Capsules, Celebrex 100mg 60 Capsules, Celebrex 200mg 30 Capsules, Celebrex 200mg 60 Capsules, Celebrex 200mg 90 Capsules, Celecoxib (Generic) 100mg 120 Capsules, Celecoxib (Generic) 100mg 180 Capsules, Celecoxib (Generic) 100mg 60 Capsules, Celecoxib (Generic) 200mg 30 Capsules, Celecoxib (Generic) 200mg 60 Capsules, Celecoxib (Generic) 200mg 90 Capsules, Cialis 10mg 16 Tablets, Cialis 10mg 24 Tablets, Cialis 10mg 32 Tablets, Cialis 10mg 8 Tablets, Cialis 20mg 16 Tablets, Cialis 20mg 24 Tablets, Cialis 20mg 32 Tablets, Cialis 20mg 8 Tablets, Conti 0.5/2.5 – 168 Tablets (6 Months), Conti 0.5/2.5 – 84 Tablets (3 months), Conti 1/5 – 168 Tablets (6 Months), Conti 1/5 – 84 Tablets (3 months), cream 45g tube, Duet 1mg – 168 Tablets (6 Months), Duet 1mg – 84 Tablets (3 months), Duet 2mg – 168 Tablets (6 Months), Duet 2mg – 84 Tablets (3 months), Duet Conti – 168 Tablets (6 Months), Etoricoxib (Generic) 120mg 28 Tablets, Etoricoxib (Generic) 120mg 56 Tablets, Etoricoxib (Generic) 120mg 84 Tablets, Etoricoxib (Generic) 30mg 28 Tablets, Etoricoxib (Generic) 30mg 56 Tablets, Etoricoxib (Generic) 30mg 84 Tablets, Etoricoxib (Generic) 60mg 28 Tablets, Etoricoxib (Generic) 60mg 56 Tablets, Etoricoxib (Generic) 60mg 84 Tablets, Etoricoxib (Generic) 90mg 28 Tablets, Etoricoxib (Generic) 90mg 84 Tablets, Evohaler/Inhaler – 1 Pack, Evohaler/Inhaler – 2 Packs, Evorel Conti 48 Patches, Evorel Sequi 24 Patches, Feldene 20mg 30 Capsules, Feldene 20mg 60 Capsules, Fosamax Daily 10mg 84 Tablets, Gel 45g tube, Millinette 30/75 – 63 tablets (3 months), Naprosyn EC 500mg 56 Tablets, Piroxicam (Generic) 20mg 56 Capsules, Piroxicam (Generic) 20mg 84 Capsules, Seretide Evohaler 125 1 Pack, Seretide Evohaler 250 1 Pack, Seretide Evohaler 50 1 Pack, Spiriva Respimat – 1 Pack, Spiriva Respimat – 2 Packs, Spiriva Respimat – 3 Packs, Tadalafil Generic 10mg 16 Tablets, Tadalafil Generic 20mg 24 Tablets

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